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P., Koh, G

Additionally, drugs like metformin and simvastatin, which can penetrate the blood-brain barrier and alter metabolic pathways, have shown great feasibility in the treatment of gliomas

That second finding is crucial

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They further validated the anti-tumor effects of this formulation at the cellular and animal levels, showing that compared to free luteolin, luteolin-loaded MPEG-PCL nanomicelles could more effectively induce apoptosis in C6 and U87 cells and inhibit neovascularization in tumor tissues